OpenEvidence to Add ACP and Annals Content to Clinical AI Platform

The American College of Physicians and OpenEvidence announced on November 9, 2026 that OpenEvidence will license ACP’s evidence-based clinical guidance and content from Annals of Internal Medicine for integration into its clinical decision-support AI platform.

Under the agreement, OpenEvidence will integrate the material for access at the point of care. The ACP portion includes clinical guidelines, guidance statements, practice points and best-practice advice developed from available evidence. The Annals portion spans original research, review articles, clinical guidelines and commentary.

The Annals content extends across clinical practice, health-care delivery, public health, health-care policy, medical education, ethics and research methodology. The agreement therefore covers different forms of clinical evidence: ACP’s recommendations turn available evidence into practice guidance, while Annals adds research, reviews and commentary that physicians can consult to examine a question in greater depth.

Expected Benefits During Patient Care

The organizations said the integrated material is intended to strengthen physicians’ confidence at the point of care and support patient-centered care. ACP president Jan K. Carney described the arrangement as an extension of the organization’s work to equip internal-medicine physicians with resources for more efficient and effective practice. “Having access to trusted, evidence-based clinical guidance from ACP and peer-reviewed content from Annals of Internal Medicine where and when they need it can help physicians make more informed clinical decisions in real time and devote more time and attention to patient care,” Carney said.

Internal Medicine’s Role in the Collaboration

Travis Zack, OpenEvidence’s chief medical officer, said internal medicine is currently the largest specialty on the platform. He described a single clinic session in which an internist might move from a heart-failure regimen to a thyroid nodule and then to a drug interaction in a patient taking ten medications. The example illustrates the breadth of questions an internal-medicine physician can face during routine practice.

The announcement reports 163,000 ACP members across internal medicine and its subspecialties and describes ACP as the largest medical specialty organization in the United States. Zack also placed the collaboration in a longer history, saying the term evidence-based medicine first appeared in print in an ACP journal in 1991 and that ACP has spent the decades since turning that idea into guidance internists can act on.

Zack emphasized the citation as part of that workflow: “Bringing ACP’s guidance and Annals of Internal Medicine into OpenEvidence means more of those answers draw on the evidence internists already trust, with the citation right there to check.”

The collaboration links a substantial internal-medicine evidence base to a platform already fielding questions across that specialty. Its practical value will depend on how effectively the planned integration makes ACP recommendations and journal articles visible and checkable during routine care, keeping AI-assisted answers connected to sources physicians can assess for themselves.